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(am i kay' sin)Amikacin may cause serious kidney problems. Kidney problems may occur more often in older people or in people that are dehydrated. Tell your doctor if you have or have ever had kidney disease. If you experience any of the following symptoms, call your doctor immediately: decreased urination; swelling of the face, arms, hands, feet, ankles, or lower legs; or unusual tiredness or weakness. Amikacin may cause serious hearing problems. Hearing problems may occur more often in older people or in people that are dehydrated. Hearing loss may be permanent in some cases. Tell your doctor if you have or have ever had dizziness, vertigo, hearing loss, or ringing in the ears. If you experience any of the following symptoms, call your doctor immediately: hearing loss, roaring or ringing in the ears, or dizziness. Amikacin may cause nerve problems. Tell your doctor if you have or have ever had burning, tingling, or numbness in the hands, arms, feet, or legs; muscle twitching or weakness; or seizures. The risk that you will develop serious kidney, hearing, or other problems is greater if you are taking certain medications. Tell your doctor and pharmacist if you are taking acyclovir (Zovirax, Sitavig); amphotericin (Abelcet, Ambisome, Amphotec); bacitracin; capreomycin (Capastat); certain cephalosporin antibiotics such as cefazolin (Ancef, Kefzol), cefixime (Suprax), or cephalexin (Keflex); cisplatin; colistin (Coly-Mycin S); cyclosporine (Gengraf, Neoral, Restasis, Sandimmune); diuretics ('water pills') such as bumetanide, ethacrynic acid (Edecrin), furosemide (Lasix), or torsemide (Demadex); other aminoglycoside antibiotics such as gentamicin, kanamycin, neomycin (Neo-Fradin), paromomycin, streptomycin or tobramycin; polymyxin B; or vancomycin (Vanocin). Your doctor may not want you to receive amikacin injection. If you are having surgery, including dental surgery, tell the doctor or dentist that you are using amikacin injection. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests, including hearing tests, before and during treatment to check your body's response to amikacin.