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Linzess (Linaclotide)

Constella (℞)
72mcg Capsule

(℞) Prescription required. Can not be split. Product of Canada. Shipped from Canada. Linzess is also marketed internationally under the name Constella.

Constella (℞)
145mcg Capsule

(℞) Prescription required. Can not be split. Product of Canada. Shipped from Canada. Linzess is also marketed internationally under the name Constella.

Constella (℞)
290mcg Capsule

(℞) Prescription required. Can not be split. Product of UK/EU. Shipped from United Kingdom. Linzess is also marketed internationally under the name Constella.


To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more


Linaclotide Information

(lin ak' loe tide)

Linaclotide may cause life-threatening dehydration in young laboratory mice. Children younger than 6 years of age should never take linaclotide. Children 6 to 17 years of age should not take linaclotide. Talk to your doctor about the risks of taking linaclotide.
Linaclotide is used in adults to treat irritable bowel syndrome with constipation (IBS-C; a condition that causes stomach pain or cramps, bloating, and infrequent or difficult passage of stools) and chronic idiopathic constipation (CIC; difficult or infrequent passage of stools that lasts for 3 months or longer and is not caused by a disease or a medication). Linaclotide is in a class of medications called guanylate cyclase-C agonists. It works by increasing the movement of food and waste through the stomach and intestines.
Linaclotide comes as a capsule to take by mouth. It is usually taken once a day on an empty stomach, at least thirty minutes before the first meal of the day. Take linaclotide at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take linaclotide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Swallow the capsules whole; do not split, chew, or crush them. Linaclotide controls the symptoms of IBS-C and CIC, but does not cure these conditions. Your constipation symptoms may improve in 1 week, and it may take slightly longer for your stomach pain to improve. Continue to take linaclotide even if you feel well. Do not stop taking linaclotide without talking to your doctor. If you stop taking linaclotide, your symptoms may return in about 1 week.
    Before taking linaclotide,
  • tell your doctor and pharmacist if you are allergic to linaclotide, any other medications, or any of the ingredients in linaclotide capsules. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have a blockage in your stomach or intestines. Your doctor will probably tell you not to take linaclotide.
  • tell your doctor if you have or have ever had any other medical conditions.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking linaclotide, call your doctor.
Unless your doctor tells you otherwise, continue your normal diet.
If you remember the missed dose before eating, take the missed dose as soon as you remember it. If you have already eaten, check with your doctor before taking the missed dose. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Linaclotide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
  • diarrhea
  • stomach pain
  • swelling or feeling of fullness or pressure in the stomach area
  • gas
  • headache
Some side effects can be serious. If you experience any of these symptoms, stop taking linaclotide and call your doctor immediately or get emergency medical treatment:
  • unusual or severe stomach pain
  • bright red or black, tarry stools
  • hives
Linaclotide may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Do not remove the desiccant (drying agent) from the bottle, if one has been provided. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Keep all appointments with your doctor. Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

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