Before taking eltrombopag,
tell your doctor and pharmacist if you are allergic to eltrombopag, any other medications, or any of the ingredients in eltrombopag tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants (blood thinners) such as warfarin (Coumadin, Jantoven); bosentan (Tracleer); cholesterol-lowering medications (statins) such as atorvastatin (Lipitor, in Caduet), fluvastatin (Lescol), pitavastatin (Livalo), pravastatin (Pravachol), rosuvastatin (Crestor), and simvastatin (Zocor, in Simcor, in Vytorin); ezetimibe (Zetia, in Vytorin); glyburide (Diabeta, Glynase, in Glucovance); imatinib (Gleevec); irinotecan (Camptosar); olmesartan (Benicar, in Azor, in Tribenzor, others); lapatinib (Tykerb); methotrexate (Trexall); mitoxantrone; repaglinide (Prandin, in PrandiMet): rifampin (Rimactane, Rifadin, in Rifamate, Rifater); sulfasalazine (Azulfidine); topotecan (Hycamtin), and valsartan (in Diovan HCT, in Entresto, in Exforge). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with eltrombopag, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
if you are taking antacids containing calcium, aluminum, or magnesium (Maalox, Mylanta, Tums) or vitamin or mineral supplements containing calcium, iron, zinc or selenium, take them 2 hours before or 4 hours after you take eltrombopag.
tell your doctor if you are of East Asian (Chinese, Japanese, Taiwanese, or Korean) descent and if you have or have ever had a cataract (clouding of the lens of the eye that may cause vision problems), blood clots, any condition that increases the risk that you will develop a blood clot, bleeding problems, or liver or kidney disease. Also tell your doctor if you have had surgery to remove your spleen.
tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking eltrombopag, call your doctor.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking eltrombopag.
continue to avoid activities that may cause injury and bleeding during your treatment with eltrombopag. Eltrombopag is given to decrease the risk that you will experience severe bleeding, but there is still a risk that bleeding may occur.