Before taking bosutinib,
tell your doctor and pharmacist if you are allergic to bosutinib or any of the ingredients in bosutinib tablets. Ask your pharmacist for a list of the ingredients.
tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antifungals such as fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), posaconazole (Noxafil), and voriconazole (Vfend); boceprevir (Victrelis); aprepitant (Emend); bosentan (Tracleer); certain medications used to treat human immunodeficiency virus (HIV) such as amprenavir (Agenerase), atazanavir (Reyataz), darunavir (Prezista), efavirenz (Sustiva), etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), and saquinavir (Invirase); medications to reduce stomach acid such as esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), and rabeprazole (AcipHex); certain medications for seizures such as carbamazepine (Tegretol), phenobarbital (Luminal), and phenytoin (Dilantin); ciprofloxacin (Cipro, Proquin XR); clarithromycin (Biaxin); digoxin (Digitek, Lanoxin); diltiazem (Cardizem, Dilacor, Tiazac); erythromycin (E.E.S., E-Mycin, Erythrocin); modafinil (Provigil); nafcillin (Unipen, Nallpen); nefazodone; rifabutin (Mycobutin); rifampin (Rimactane, Rifadin, in Rifater, in Rifamate); telaprevir (Incivek); telithromycin (Ketek); and verapamil (Calan, Isoptin, Verelan). Many other medications may also interact with bosutinib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
if you are taking antacids, such as aluminum hydroxide/magnesium hydroxide (Maalox), calcium carbonate (Tums) or calcium carbonate and magnesium (Rolaids) or medications to reduce stomach acid, such as cimetidine (Tagamet), famotidine (Pepcid), or ranitidine (Zantac), take them 2 hours before or 2 hours after you take bosutinib.
tell your doctor what herbal products you are taking, especially St. John's wort.
tell your doctor if you have or have ever had liver or heart disease.
tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while you are taking bosutinib. You should use an effective form of birth control during treatment with bosutinib and for one month after treatment. Talk to your doctor about birth control methods that will work for you. If you become pregnant while taking bosutinib, call your doctor. Bosutinib may harm the fetus.
tell your doctor if you are breast-feeding. You should not breast-feed while you are taking bosutinib.