Pegfilgrastim comes as a solution (liquid) in prefilled injection syringes and in a pre-filled automatic injection device (On-body Injector) to inject subcutaneously (under the skin). If you are using pegfilgrastim to decrease the risk of infection during chemotherapy, it is usually given as a single dose for each chemotherapy cycle, no sooner than 24 hours after the last dose of chemotherapy of the cycle is given and more than 14 days before beginning the next chemotherapy cycle. If you are using pegfilgrastim because you have been exposed to harmful amounts of radiation, it is usually given as 2 single doses, one week apart. Your doctor will tell you exactly when you should use pegfilgrastim.
Pegfilgrastim may be given to you by a nurse or other healthcare provider, or you may be told to inject the medication at home. If you will be injecting pegfilgrastim at home, follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use pegfilgrastim exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.
If you will be injecting pegfilgrastim yourself, a healthcare provider will show you how to inject the medication. Be sure that you understand these directions. Ask your healthcare provider if you have any questions about where on your body you should inject pegfilgrastim, how to give the injection, or how to dispose of used needles and syringes after you inject the medication.
If your pegfilgrastim comes in a pre-filled automatic injection device (On-body Injector), the device will usually be applied to your abdomen or the back of your arm by a nurse or other healthcare provider the day before you will receive the dose of pegfilgrastim. The next day (approximately 27 hours after the On-Body Injector was applied to your skin), the dose of pegfilgrastim will be automatically injected over 45 minutes.
When you have the pegfilgrastim pre-filled automatic injection device (On-body Injector) in place;
- you should have a caregiver with you the first time you receive a dose of pegfilgrastim or anytime the On-body injector is applied to the back of your arm.
- you will need to monitor the On-body Injector while the entire dose of pegfilgrastim is injected in your body, so you should avoid activities and being in places that may interfere with monitoring while you are receiving the dose of filgrastim and for 1 hour afterwards.
- you should not travel, drive a car, or operate machinery 1 hour before and 2 hours after you receive your dose of pegfilgrastim with the On-Body Injector.
- you should make sure that you keep the On-Body Injector at least 4 inches away from electric appliances and equipment including cell phones, cordless telephones, and microwave ovens.
- you should avoid airport x-rays and request a manual pat down if you have to travel after the On-body Injector is applied to your body and before you receive your dose of pegfilgrastim.
- you should immediately remove the On-body Injector if you have an allergic reaction while you are receiving your dose of pegfilgrastim by grabbing the edge of the adhesive pad and peeling it off. Call your doctor immediately and get emergency medical treatment.
- you should call your doctor immediately if the On-body Injector device comes off of your skin, if the adhesive becomes noticeably wet, if you see dripping from the device, or if the status light flashes red. You should keep the On-body Injector dry for 3 hours before you receive your dose of pegfilgrastim to help you notice if your device starts to leak while you are receiving your dose.
- you should avoid being exposed to medical imaging studies (X-ray scan, MRI, CT scan, ultrasound) or oxygen rich environments (hyperbaric chambers).
- you should avoid sleeping or applying pressure on the On-body Injector device.
- you should avoid hot tubs, whirlpools, saunas, and direct sunlight.
- you should avoid using lotions, oils, creams, and cleansers on your skin near the On-body Injector device.
Carefully read the manufacturer's instructions to learn about the On-Body Injector. Follow these directions carefully. Ask your doctor or pharmacist if you have questions about the On-Body Injector.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.