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(in" ter feer' on al' fa too bee)Interferon alfa-2b injection may cause or worsen the following conditions that may be serious or life-threatening: infections; mental illness, including depression, mood and behavior problems, or thoughts of hurting or killing yourself or others; ischemic disorders (conditions in which there is poor blood supply to an area of the body) such as angina (chest pain) or heart attack; and autoimmune disorders (conditions in which the immune system attacks one or more parts of the body that may affect the blood, joints, kidneys, liver, lungs, muscles, skin, or thyroid gland). Tell your doctor if you have an infection; or if you have or have ever had an autoimmune disease, psoriasis (a skin disease in which red, scaly patches form on some areas of the body), systemic lupus erythematosus (SLE or lupus; an autoimmune disease in which the immune system attacks healthy parts of the body), sarcoidosis (a condition in which small clumps of immune cells form in various organs such as the lungs, eyes, skin, and heart and interfere with the function of these organs), or rheumatoid arthritis (RA; a condition in which the body attacks its own joints, causing pain, swelling, and loss of function); cancer; colitis (inflammation of the intestine); diabetes; heart attack; high blood pressure; high triglyceride levels (fats related to cholesterol); HIV (human immunodeficiency virus) or AIDS (acquired immunodeficiency syndrome); irregular heartbeat; mental illness including depression, anxiety, or thinking about or trying to kill yourself; or heart, kidney, pancreas, or thyroid disease. If you experience any of the following symptoms, call your doctor immediately: bloody diarrhea or bowel movements; fever, chills, cough with phlegm (mucus), sore throat, or other signs of infection; urinating more frequently or with pain, chest pain; irregular heartbeat; changes in your mood or behavior; depression; starting to use street drugs or alcohol again if you used them in the past; irritability (getting upset easily); thoughts of killing or hurting yourself; aggressive or violent behavior; difficulty breathing; chest pain; changes in walking or speech; decreased strength or weakness on one side of your body; blurred vision or loss of vision; severe stomach pain; unusual bleeding or bruising; dark colored urine; light colored bowel movements; or worsening of an autoimmune disease. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to interferon alfa-2b.