Before taking lomitapide,
tell your doctor and pharmacist if you are allergic to lomitapide, any other medications, or any of the ingredients in lomitapide capsules. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
tell your doctor if you are taking antifungal medications such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), and voriconazole (Vfend); boceprevir (Victrelis); aprepitant (Emend); ciprofloxacin (Cipro); clarithromycin (Biaxin); crizotinib (Xalkori); diltiazem (Cardizem, Dilacor, Tiazac); erythromycin (E.E.S., E-Mycin, Erythrocin); HIV protease inhibitors such as amprenavir (Agenerase), atazanavir (Reyataz), darunavir (Prezista), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir (in Kaletra), nelfinavir (Viracept), saquinavir (Invirase), ritonavir (Norvir, in Kaletra), ritonavir and tipranavir (Aptivus), and teleprevir (Incivek); imatinib (Gleevec); nefazodone; telithromycin (Ketek); and verapamil (Calan, Covera, Isoptin, Verelan). Your doctor will probably tell you not to take lomitapide if you are taking one or more of these medications.
tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: aliskiren (Tekturna); alprazolam (Xanax); ambrisentan (Letairis); amiodarone (Cordarone, Pacerone); amlodipine (Norvasc, in Caduet); bicalutamide (Casodex); cilostazol (Pletal); certain oral medications for diabetes such as saxagliptin (Onglyza in Kombiglyze) and sitagliptin (Januvia, in Janumet); cimetidine (Tagament); colchicine (Colcrys); dabigatran (Pradaxa); digoxin (Lanoxin); everolimus (Afinitor, Zortress); fexofenadine (Allegra); fluoxetine (Prozac); fluvoxamine (Luvox); isoniazid (INH, Nydrazid); lapatinib (Tykerb); maraviroc (Selzentry); medications that suppress the immune system such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune) and tacrolimus (Prograf); nilotinib (Tasigna); oral contraceptives (birth control pills); other cholesterol lowering medications such as atorvastatin (Lipitor, in Caduet, in Liptruzet), lovastatin (Mevacor), and simvastatin (Zocor, in Simcor, in Vytorin); pazopanib (Votrient); ranitidine (Zantac); ranolazine (Ranexa); ticagrelor (Brilinta); tolvaptan (Samsca); topotecan (Hycamtin); warfarin (Coumadin); and zileuton (Zyflo). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with lomitapide, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
tell your doctor what herbal products you are taking, especially ginkgo or goldenseal.
if you are taking cholestyramine (Questran), colesevelam (WellChol), or colestipol (Colestid), take it 4 hours before or 4 hours after lomitapide.
tell your doctor if you have or have ever had galactose intolerance or glucose-galactose malabsorption (inherited conditions where the body is not able to tolerate lactose), ongoing stomach or intestinal problems, or pancreas or kidney disease.
Tell your doctor if you are pregnant or plan to become pregnant. If you are female who can become pregnant, you will need to take a pregnancy test before you begin taking lomitapide. If you can become pregnant, you should use effective birth control while taking lomitapide. Talk to your doctor about birth control methods that will work for you. If you become pregnant while taking lomitapide, stop taking the medication and call your doctor immediately. Lomitapide can harm the fetus.
tell your doctor if you are breast-feeding. You should not breast-feed while you are taking lomitapide.