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Dulaglutide injection may increase the risk that you will develop tumors of the thyroid gland, including medullary thyroid carcinoma (MTC; a type of thyroid cancer). Laboratory animals who were given dulaglutide developed tumors, but it is not known if this medication increases the risk of tumors in humans.Tell your doctor if you or anyone in your family has or has ever had MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2; condition that causes tumors in more than one gland in the body). If so, your doctor will probably tell you not to use dulaglutide injection. If you experience any of the following symptoms, call your doctor immediately: a lump or swelling in the neck; hoarseness; difficulty swallowing; or shortness of breath.
Keep all appointments with your doctor and the laboratory. Your doctor may order certain tests to check your body's response to dulaglutide injection.
Talk to your doctor about the risks of using dulaglutide injection.
Dulaglutide injection is used with a diet and exercise program to control blood sugar levels in adults with type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood) when other medications did not control levels well enough. Dulaglutide injection is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may develop if high blood sugar is not treated). Dulaglutide injection is in a class of medications called incretin mimetics. It works by helping the pancreas to release the right amount of insulin when blood sugar levels are high. Insulin helps move sugar from the blood into other body tissues where it is used for energy. Dulaglutide injection also works by slowing the movement of food through the stomach.
Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Using medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.
Dulaglutide injection comes as a solution (liquid) in a prefilled dosing pen or prefilled syringes to inject subcutaneously (under the skin) in your stomach, thigh, or upper arm. It is usually injected once a week without regard to meals. Use dulaglutide injection on the same day each week at any time of day. You may change the day of the week that you use dulaglutide as long as it has been 3 or more days since you used your last dose. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use dulaglutide injection exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.
Dulaglutide injection controls diabetes but does not cure it. Continue to use dulaglutide injection even if you feel well. Do not stop using dulaglutide injection without talking to your doctor.
Dulaglutide comes in prefilled dosing pens and prefilled syringes that contain enough medication for one dose. Always inject dulaglutide in its own prefilled dosing pen or syringe; never mix it with any other medication.
Carefully read the manufacturer's instructions for use that comes with the medication. These instructions describe how to prepare and inject a dose of dulaglutide injection. Be sure to ask your pharmacist or doctor if you have any questions about how to inject this medication.
Always look at dulaglutide solution before you inject it. It should be clear, colorless, and free of solid particles.
You can inject dulaglutide in your upper arm, thigh, or stomach area. Never inject dulaglutide into a vein or muscle. Change (rotate) the injection site within the chosen area with each dose. You can inject dulaglutide and insulin in the same body area, but you should not give the injections right next to each other.
Never reuse or share needles or pens. Dispose of needles in a puncture-resistant container. Ask your doctor or pharmacist how to dispose of the puncture resistant container.
Before using dulaglutide,
- tell your doctor and pharmacist if you are allergic to dulaglutide, any other medications, or any of the ingredients in dulaglutide injection. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. It is especially important to tell your doctor about all the medications you take by mouth because dulaglutide may change the way your body absorbs these medications. Also be sure to mention insulin or oral medications for diabetes especially sulfonylureas, including chlorpropamide (Diabinese), glimepiride (Amaryl, in Avandaryl, in Duetact), glipizide (Glucotrol), glyburide (DiaBeta, in Glucovance), tolazamide, and tolbutamide. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have or have ever had pancreatitis (inflammation of the pancreas); severe stomach problems, including gastroparesis (slowed movement of food from the stomach to the small intestine) or other problems digesting food; or kidney or liver disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using dulaglutide injection, call your doctor.
- ask your doctor what to do if you get sick, develop an infection or fever, experience unusual stress, or are injured. These conditions can affect your blood sugar and the amount of dulaglutide you may need.
Be sure to follow all exercise and dietary recommendations made by your doctor or dietitian.
Use the missed dose as soon as you remember it and then continue your regular weekly schedule. However, if there are less than 3 days until your next scheduled dose, skip the missed dose and continue your regular dosing schedule. Do not use a double dose to make up for a missed one.
This medication may cause changes in your blood sugar. You should know the symptoms of low and high blood sugar and what to do if you have these symptoms.
Dulaglutide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- decreased appetite
- feeling tired
Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, stop taking dulaglutide and call your doctor immediately or get emergency medical treatment:
- ongoing pain that begins in the upper left or middle of the stomach but may spread to the back
- difficulty breathing
- swelling of the lips and face
Dulaglutide may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
Keep this medication in the original carton in the refrigerator, protected from light. Do not freeze. If necessary, each prefilled dosing pen or prefilled syringe can be kept at room temperature for up to 14 days. Keep dulaglutide out of reach of children.
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.