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Omalizumab injection may cause serious or life-threatening allergic reactions. You may experience an allergic reaction immediately after receiving a dose of omalizumab injection or up to 4 days later. Also, an allergic reaction can occur after you receive the first dose of medication or at any time during your treatment with omalizumab. Tell your doctor if you are allergic to omalizumab injection, and if you have or have ever had food or seasonal allergies, a serious or life-threatening allergic reaction to any medication, or sudden breathing problems.
You will receive each injection of omalizumab in a doctor's office or medical facility. You will stay in the office for some time after you receive the medication so your doctor can watch you closely for any signs of an allergic reaction. Tell your doctor if you experience any of the following symptoms: wheezing or difficulty breathing, shortness of breath, cough, chest tightness, dizziness, fainting, fast or weak heartbeat, anxiety, feeling that something bad is about to happen, flushing, itching, hives, feeling warm, swelling of the throat or tongue, throat tightness, hoarse voice, or difficulty swallowing. Call your doctor immediately or get immediate emergency medical attention if you experience any of these symptoms after you leave your doctor's office or medical facility.
Talk to your doctor about the risks of receiving omalizumab injection.
Omalizumab injection is used to decrease the number of asthma attacks (sudden episodes of wheezing, shortness of breath, and trouble breathing) in people with allergic asthma (asthma caused by inhaling substances such as dander, pollen, and dust mites) whose symptoms are not controlled with inhaled steroids. Omalizumab is also used to treat chronic hives without a known cause that cannot successfully be treated with antihistamine medications such as diphenhydramine (Benadryl), cetirizine (Zyrtec), hydroxyzine (Vistaril), and loratadine (Claritin). Omalizumab is not used to treat other forms of hives or allergic conditions. Omalizumab injection is in a class of medications called monoclonal antibodies. It works by blocking the action of a certain natural substance in the body that causes the symptoms of allergic asthma and hives.
Omalizumab injection comes as a powder to be mixed with water and injected subcutaneously (under the skin). When omalizumab is used to treat allergic asthma, it is usually injected once every 2 or 4 weeks. You may receive one or more injections at each visit, depending on your weight and medical condition. When omalizumab is used to treat chronic hives, it is usually given once every 4 weeks. Your doctor will determine the length of your treatment based on your condition and how well you respond to the medication.
It may take some time before you feel the full benefit of omalizumab injection. Do not decrease your dose of any other asthma or hives medication or stop taking any other medication that has been prescribed by your doctor unless your doctor tells you to do so. Your doctor may want to decrease the doses of your other medications gradually.
Omalizumab injection is not used to treat a sudden attack of asthma symptoms. Your doctor will prescribe a short-acting inhaler to use during attacks. Talk to your doctor about how to treat symptoms of a sudden asthma attack. If your asthma symptoms get worse or if you have asthma attacks more often, be sure to talk to your doctor.
Before receiving omalizumab injection,
- tell your doctor and pharmacist if you are allergic to any medications or any of the ingredients in omalizumab injection. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: allergy shots (a series of injections given regularly to prevent the body from developing allergic reactions to specific substances) and medications that suppress your immune system. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have or have ever had cancer.
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using omalizumab injection, call your doctor.
- talk to your doctor about whether there is a risk that you will develop a hookworm, roundworm, whipworm, or threadworm infection (infection with worms that live inside the body). Tell your doctor if you have or have ever had any type infection caused by worms. If you are at high risk of developing this type of infection, using omalizumab injection may increase the chance that you will actually become infected. Your doctor will monitor you carefully during and after your treatment.
Unless your doctor tells you otherwise, continue your normal diet.
If you miss an appointment to receive omalizumab injection, call your doctor as soon as possible.
Omalizumab injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- pain, redness, swelling, warmth, burning, bruising, hardness, or itching in the place omalizumab was injected
- pain, especially in the joints, arms, or legs
- ear pain
- swelling inside of the nose, throat, or sinuses
Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section or the SPECIAL PRECAUTIONS section, call your doctor immediately or get emergency medical treatment:
- fever, muscle aches, rash, and swollen glands within 1 to 5 days after receiving a dose of omalizumab injection
- shortness of breath
- coughing up blood
- skin sores
- severe pain, numbness and tingling in your hands and feet
Some people who received omalizumab injection have had chest pain, heart attacks, blood clots in the lungs or legs, temporary symptoms of weakness on one side of the body, slurred speech, and changes in vision. There is not enough information to determine whether these symptoms are caused by omalizumab injection.
Omalizumab injection may increase the risk of developing certain types of cancer. There is not enough information to determine whether these cancers are caused by omalizumab injection.
Talk to your doctor about the risks of using this medication.
Omalizumab injection may cause other side effects. Call your doctor if you have any unusual problems while using this medication.
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to omalizumab injection.
Before having any laboratory test, tell your doctor and the laboratory personnel that you are receiving omalizumab injection or if you have received omalizumab injection within the past year.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.